Optimal Sampling of Rat Liver Tissue for Toxicogenomic Studies

Toxicogenomic Biomarkers for Liver Toxicity

Toxicogenomics (TGx) is a widely used technique in the preclinical stage of drug development to investigate the molecular mechanisms of toxicity. A number of candidate TGx biomarkers have now been identified and are utilized for both assessing and predicting toxicities. Further accumulation of novel TGx biomarkers will lead to more efficient, appropriate and cost effective drug risk assessment,...

Determination of Optimal Sampling Design for Spatial Data Analysis

Extended Abstract. Inferences for spatial data are affected substantially by the spatial configuration of the network of sites where measurements are taken. Consider the following standard data-model framework for spatial data. Suppose a continuous, spatially-varying quantity, Z, is to be observed at a predetermined number, n, of points ....[ To Countinue Click here]

Optimal sampling strategies for two-stage studies.

The optimal allocation of available resources is the concern of every investigator in choosing a study design. The recent development of statistical methods for the analysis of two-stage data makes these study designs attractive for their economy and efficiency. However, little work has been done on deriving two-stage designs that are optimal under the kinds of constraints encountered in practi...

Sensitivity Analysis of Spatial Sampling Designs for Optimal Prediction

In spatial statistic, the data analyzed which is correlated and this correlation is due to their locations in the studied region. Such correlation that is related to distance between observations is called spatial correlation. Usually in spatial data analysis, the prediction of the amount of uncertain quantity in arbitrary 4locations of the area is considered according to attained observations ...

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.